張志燕，江西農(nóng)大動(dòng)物遺傳育種與繁殖專業(yè), 博士，副研究員。比利時(shí)列日大學(xué)獸醫(yī)學(xué)院數(shù)量遺傳學(xué)博士, 師從黃路生教授和Michel Georges 教授。主要從事家豬復(fù)雜經(jīng)濟(jì)性狀及抗病性狀的 QTL 定位、精細(xì)定位研究、基于單倍型的線性混合模型的全基因組關(guān)聯(lián)分析算法和應(yīng)用及利用已有的高密度基因型個(gè)體作為參考群體, 推斷出低密度基因型個(gè)體所有基因型方法(imputation)及其在關(guān)聯(lián)分析和基因組選擇育種方面的研究。近年來主持國(guó)家自然科學(xué)基金項(xiàng)目4項(xiàng)，以科研骨干參與5項(xiàng)。共發(fā)表SCI文章60余篇，其中第一或通訊（共同第一）作者文章15篇，獲發(fā)明專利三項(xiàng)。
教育經(jīng)歷
2008/11–2013/11，University of Liege，數(shù)量遺傳學(xué)，博士，導(dǎo)師：黃路生 & Michel Georges
2005/9–2008/7，江西農(nóng)業(yè)大學(xué)，動(dòng)物遺傳育種與繁殖，碩士,導(dǎo)師：黃路生
2001/9–2005/7，西北農(nóng)林科技大學(xué),生物技術(shù)，學(xué)士，導(dǎo)師：范三紅
工作經(jīng)歷
2016/10-至今，江西農(nóng)業(yè)大學(xué)動(dòng)物科學(xué)技術(shù)學(xué)院，豬遺傳改良與養(yǎng)殖技術(shù)省部共建國(guó)家重點(diǎn)實(shí)驗(yàn)室，副研究員
2012/1-2016/10，江西農(nóng)業(yè)大學(xué)，豬遺傳改良與養(yǎng)殖技術(shù)省部共建共建重點(diǎn)實(shí)驗(yàn)室，助理研究員
2008/7-2011/12，江西農(nóng)業(yè)大學(xué)，豬遺傳改良與養(yǎng)殖技術(shù)省部共建共建重點(diǎn)實(shí)驗(yàn)室，研究實(shí)習(xí)員
代表性研究成果和學(xué)術(shù)獎(jiǎng)勵(lì)情況：
1).Guorong Yan, Tianfu Guo, Shijun Xiao, Feng Zhang, Wenshui Xin, Tao Huang, Yiping Li, Wenwu Xu, Lusheng Huang, Zhiyan Zhang, Imputation-Based Whole-Genome Sequence Association Study Reveals Constant and Novel Loci for Hematological Traits in a Large-Scale Swine F2 Resource Population Frontiers in Genetics, 2018, 9(401): 1-12.
2).Xu Wenwu, Chen Dong, Yan Guorong, Xiao Shijun, Huang Tao, Zhang Zhiyan*; Huang Lusheng*, Rediscover and Refine QTLs for Pig Scrotal Hernia by Increasing a Specially Designed F-3 Population and Using Whole-Genome Sequence Imputation Technology, Frontiers in Genetics, 2019, 10: 0-890.
3).Zhang Z., Guillaume F., Sartelet A., Charlier C., Georges M., Farnir F., Druet T., Ancestral haplotype-based association mapping with generalized linear mixed models accounting for stratification, Bioinformatics. 28 (2012) 2467-2473.(IF=5.323)
4).He Yuna#, Li Xinjian#, Zhang Feng, Su Ying, Hou Lijuan, Chen Hao, Zhang Zhiyan*, Huang Lusheng*, Multi-breed genome-wide association study reveals novel loci associated with the weight of internal organs, Genet Sel Evol, 2015, 47:87-87
5).Yan Guorong, Qiao Ruimin, Zhang Feng, Xin Wenshui, Xiao Shijun, Huang Tao, Zhang Zhiyan*, Huang Lusheng, Imputation-Based Whole-Genome Sequence Association Study Rediscovered the Missing QTL for Lumbar Number in Sutai Pigs, Scientific Reports, 2017,7
6).Zhang Z., Hong Y., Gao J., Xiao S., Ma J., Zhang W., Ren J., Huang L., Genome-wide association study reveals constant and specific loci for hematological traits at three time stages in a White Duroc x Erhualian F2 resource population, PLoS One. 8 (2013) e63665.(IF=3.73)
7).Zhang Z., Druet T., Marker imputation with low-density marker panels in Dutch Holstein cattle, J Dairy Sci. 93 (2010) 5487-5494. (IF=2.566)
8).Zhang Z.Y., Ren J., Ren D.R., Ma J.W., Guo Y.M., Huang L.S., Mapping quantitative trait loci for feed consumption and feeding behaviors in a White Duroc x Chinese Erhualian resource population, J Anim Sci. 87 (2009) 3458-3463. (IF=2.093，農(nóng)林科學(xué)類2區(qū))
9).Zhang, Feng*; Zhang, Zhiyan*; Yan, Xueming; Chen, Hao; Zhang, Wanchang; Hong, Yuan; Huang, Lusheng，Genome-wide association studies for hematological traits in Chinese Sutai pigs，BMC Genetics，（2014），1471-2156
10).Wenshui Xin; Xinjian Li; Feng Zhang; Guorong Yan; Nengshui Ding; Lusheng Huang; Zhiyan Zhang，A multi-population survey on swine feeding behavior with electronic feeding devices，Archives of Animal Breeding，（2016），445-452
11).Zhao, Xueyan; Zhao, Kewei; Ren, Jun; Zhang, Feng; Jiang, Chao; Hong, Yuan; Jiang, Kai; Yang, Qiang; Wang, Chengbin; Ding, Nengshui; Huang, Lusheng; Zhang, Zhiyan#; Xing, Yuyun#，An imputation-based genome-wide association study on traits related to male reproduction in a White DurocxErhualian F-2 population，Animal Science Journal，（2016），646-654
12).Ji, Jiuxiu; Yan, Guorong; Chen, Dong; Xiao, Shijun; Gao, Jun#; Zhang, Zhiyan#，An association study using imputed whole-genome sequence data identifies novel significant loci for growth-related traits in a Duroc x Erhualian F2 population，Journal of Animal Breeding and Genetics，（2019），217-228
13).Xin W S; Zhang F; Yan G R; Xu W W; Xiao S J; Zhang Z Y#; Huang L S#，A whole genome sequence association study for puberty in a large DurocxErhualian F2 population，Animal Genetics，（2018），29-35
14).Durkin K., Coppieters W., Drogemuller C., Ahariz N., Cambisano N., Druet T., Fasquelle C., Haile A., Horin P., Huang L., Kamatani Y., Karim L., Lathrop M., Moser S., Oldenbroek K., Rieder S., Sartelet A., Solkner J., Stalhammar H., Zelenika D., Zhang Z., Leeb T., Georges M., Charlier C., Serial translocation by means of circular intermediates underlies colour sidedness in cattle, Nature. 482 (2012) 81-84. (IF=38.597)
15).Dupuis M.C., Zhang Z., Durkin K., Charlier C., Lekeux P., Georges M., Detection of copy number variants in the horse genome and examination of their association with recurrent laryngeal neuropathy, Anim Genet. 44 (2013) 206-208. (IF=2.584)
16).Dupuis M.C., Zhang Z., Druet T., Denoix J.M., Charlier C., Lekeux P., Georges M., Results of a haplotype-based GWAS for recurrent laryngeal neuropathy in the horse, Mamm Genome. 22 (2011) 613-620. (IF=2.419)
17).Blard G., Zhang Z., Coppieters W., Georges M., Identifying cows with subclinical mastitis by bulk single nucleotide polymorphism genotyping of tank milk, J Dairy Sci. 95 (2012) 4109-4113. (IF=2.566)
18).Ren J., Mao H., Zhang Z., Xiao S., Ding N., Huang L., A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs, Heredity (Edinb). 106 (2011) 862-868. (IF=4.11)
19).Li K., Ren J., Xing Y., Zhang Z., Ma J., Guo Y., Huang L., Quantitative trait loci for litter size and prenatal loss in a White Duroc x Chinese Erhualian resource population, Anim Genet. 40 (2009) 963-966. (IF=2.584)
20).Yang G., Ren J., Zhang Z., Huang L., Genetic evidence for the introgression of Western NR6A1 haplotype into Chinese Licha breed associated with increased vertebral number, Anim Genet. 40 (2009) 247-250. (IF=2.584)
21).Yang Z.Q., Ren J., Zhang Z.Y., Chen C.Y., [Genetic variation and association of prostaglandin F2alpha receptor (PTGFR) gene with sow maternal behaviors in a White Duroc x Erhualian resource population], Yi Chuan. 32 (2010) 1147-1152.
22).Ren J., Duan Y., Qiao R., Yao F., Zhang Z., Yang B., Guo Y., Xiao S., Wei R., Ouyang Z., Ding N., Ai H., Huang L., A missense mutation in PPARD causes a major QTL effect on ear size in pigs, PLoS Genet. 7 (2011) e1002043. (IF=8.517)
23).Yan X.M., Ren J., Huang X., Zhang Z.Y., Ouyang J., Zeng W.H., Zou Z.Z., Yang S.J., Yang B., Huang L.S., Comparison of production traits between pigs with and without the Escherichia coli F4 receptors in a White Duroc x Erhualian intercross F2 population, J Anim Sci. 87 (2009) 334-339. (IF=2.093，農(nóng)林科學(xué)類2區(qū))
24).Chen C., Guo Y., Yang G., Yang Z., Zhang Z., Yang B., Yan X., Perez-Enciso M., Ma J., Duan Y., Brenig B., Huang L., A genome wide detection of quantitative trait loci on pig maternal infanticide behavior in a large scale White Duroc x Erhualian resource population, Behav Genet. 39 (2009) 213-219. (IF=2.606)
25).Ouyang J., Zeng W., Ren J., Yan X., Zhang Z., Yang M., Han P., Huang X., Ai H., Huang L., Association of B3GNT5 polymorphisms with susceptibility to ETEC F4ab/ac in the white Duroc x Erhualian intercross and 15 outbred pig breeds, Biochem Genet. 50 (2012) 19-33. (IF=0.938)
26).Guo T., Ren J., Yang K., Ma J., Zhang Z., Huang L., Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: results from a White Duroc x Erhualian intercross F2 population, Anim Genet. 40 (2009) 185-191. (IF=2.584)
27).Yang S., Ren J., Yan X., Huang X., Zou Z., Zhang Z., Yang B., Huang L., Quantitative trait loci for porcine white blood cells and platelet-related traits in a White Duroc x Erhualian F resource population, Anim Genet. 40 (2009) 273-278. (IF=2.584)
28).Zhang B., Ren J., Yan X., Huang X., Ji H., Peng Q., Zhang Z., Huang L., Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac, Anim Genet. 39 (2008) 258-266. (IF=2.584)
29).Zou Z., Ren J., Yan X., Huang X., Yang S., Zhang Z., Yang B., Li W., Huang L., Quantitative trait loci for porcine baseline erythroid traits at three growth ages in a White Duroc x Erhualian F(2) resource population, Mamm Genome. 19 (2008) 640-646. (IF=2.419)
30).Ji H., Ren J., Yan X., Huang X., Zhang B., Zhang Z., Huang L., The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac, Mol Biol Rep. 38 (2011) 1593-1601. (IF=2.5.6)
31).Sartelet A., Druet T., Michaux C., Fasquelle C., Geron S., Tamma N., Zhang Z., Coppieters W., Georges M., Charlier C., A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response, PLoS Genet. 8 (2012) e1002581. (IF=8.517)
32).Guo Y., Mao H., Ren J., Yan X., Duan Y., Yang G., Ren D., Zhang Z., Yang B., Ouyang J., Brenig B., Haley C., Huang L., A linkage map of the porcine genome from a large-scale White Duroc x Erhualian resource population and evaluation of factors affecting recombination rates, Anim Genet. 40 (2009) 47-52. (IF=2.584)
主持或參加科研項(xiàng)目及人才計(jì)劃項(xiàng)目情況
1. 國(guó)家自然科學(xué)基金地區(qū)項(xiàng)目，利用高覆蓋度甲基化測(cè)序技術(shù)系統(tǒng)解析豬時(shí)序特異、品種特異、組織特異的甲基化基因，31760656，38萬元，2018/01-2021/12，在研，主持
2. 國(guó)家自然科學(xué)基金應(yīng)急管理項(xiàng)目，全基因組重測(cè)序關(guān)聯(lián)分析定位豬陰囊疝疾病易感位點(diǎn)，31640046，15萬元，2017/01-2017/12，已結(jié)題，主持
3. 國(guó)家自然科學(xué)基金地區(qū)基金項(xiàng)目，豬7號(hào)染色體上影響料肉比主效QTL的分子機(jī)理，31460590，55萬元，2015/01-2018/12，已結(jié)題，參與
4. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，31402058，構(gòu)建豬基因組的重組熱點(diǎn)圖譜及重組熱點(diǎn)相關(guān)PRDM9基因的研究，2015/01-2017/12，25萬元，已結(jié)題，參與
5. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，31402100，煙酸調(diào)控湘中黑牛肌內(nèi)脂肪（IMF）沉積的機(jī)理研究,31402100，24萬元，2015/01-2017/12，已結(jié)題，參與
6. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，解析豬外耳面積因果突變PPARD G32E的分子機(jī)理，31301950，2014/01-2016/12，23萬元，已結(jié)題，參與
7. 國(guó)家自然科學(xué)青年科學(xué)基金項(xiàng)目，31200926，解析豬16號(hào)染色體上影響肌肉飽和脂肪酸含量(C20:0)主效QTL的分子遺傳機(jī)理，2013/01-2015/12，21萬元，已結(jié)題，主持
8. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，31101697，豬15號(hào)染色體上顯著影響肉PH值的父本印跡基因的精細(xì)定位于鑒別，2012/01-2014/12，25萬元，已結(jié)題，參與。
